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There are clear dose-dependent toxic effects seen with FLUDARA FOR INJECTION.
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Allergic reactions as a result of sensitivity to lidocaine are extremely rare and, if they occur, should be managed by conventional means.
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Patients at risk for cardiogenic pulmonary edema may have risk factors for heart disease, including high blood pressure, high cholesterol, diabetes, family history of heart disease, and smoking.
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In a multifactor disease (involving genes, environment, and other factors), variations in one or more genes may produce a greater likelihood of getting the disease.
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The syndrome is characterized by rhythmical involuntary movement of the tongue, face, mouth or jaw (e.g., protrusion of tongue, puffing of cheeks, puckering of mouth, chewing movements).
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Intravenous barbiturates, anticonvulsant agents, or muscle relaxants should only be administered by those familiar with their use.
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An intravascular injection is still possible even if aspirations for blood are negative.
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The area is draped in cloth and an anesthetic is applied to numb the area.
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The first step in the management of systemic toxic reactions, as well as underventilation or apnea due to unintentional subarachnoid injection of drug solution, consists of immediate attention to the establishment and maintenance of a patent airway and effective assisted or controlled ventilation with 100% oxygen with a delivery system capable of permitting immediate positive airway pressure by mask.